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Lekovi za potenciju mogu biti bezbedni za upotrebu ako se uzimaju u skladu s uputama i preporukama lečnika ili farmaceuta. Neki ljudi mogu biti u većem riziku od nuspojava od drugih, posebno oni koji uzimaju druge lijekove, imaju određene zdravstvene probleme ili su starije dobi.
Pacijentima koji žele da počnu da uzimaju lekove koji imaju klirens kreatinina (CrCl) od 30 mL se generalno savetuje da koriste manju dozu. Ovim pacijentima se preporučuje oko twenty five mg da počnu da koriste, jer bi veća doza potencijalno mogla da izazove dalje zdravstvene probleme.
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بعض المضادات الحيوية، مثل الكلاريثروميسين، والإريثروميسين، والتيليثروميسين؛ حيث يؤدي الاستعمال المتزامن إلى انخفاض ضغط الدم، والدوخة، والإغماء، ومشاكل في الرؤية.